Intramacrophage Mycobacterium tuberculosis efflux pump gene regulation after rifampicin and verapamil exposure | Zendy

Pedro Henrique Canezin | Zendy; Katiany Rizzieri Caleffi-Ferracioli | Zendy; Regiane Bertin de Lima Scodro | Zendy; Vera Lúcia Dias Siqueira | Zendy; Fernando R. Pavan | Zendy; Isabella Letícia Esteves Barros | Zendy; Rosilene Fressatti Cardoso | Zendy

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Intramacrophage Mycobacterium tuberculosis efflux pump gene regulation after rifampicin and verapamil exposure

Author(s) -

Pedro Henrique Canezin,

Katiany Rizzieri Caleffi-Ferracioli,

Regiane Bertin de Lima Scodro,

Vera Lúcia Dias Siqueira,

Fernando R. Pavan,

Isabella Letícia Esteves Barros,

Rosilene Fressatti Cardoso

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky091

Subject(s) - rifampicin , verapamil , efflux , microbiology and biotechnology , mycobacterium tuberculosis , pharmacology , biology , chemistry , antibiotics , tuberculosis , medicine , biochemistry , pathology , calcium , organic chemistry

Since resistance of Mycobacterium tuberculosis (Mtb) partially derives from efflux pumps (EPs) in the plasma membrane, the current study evaluates EPs in Mtb exposed to rifampicin in the presence of the EP inhibitor verapamil, within a macrophage environment.

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