Open AccessTemocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations
Author(s) -
Ana C. Miranda Bastos,
Stefaan J. Vandecasteele,
Anne Spinewine,
Paul M. Tulkens,
Françoise Van Bambeke
Publication year - 2018
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dky078
Subject(s) - pharmacokinetics , dosing , monte carlo method , population pharmacokinetics , medicine , pharmacology , population , mathematics , statistics , environmental health
To develop a population model describing temocillin pharmacokinetics (PK) in patients undergoing haemodialysis and investigate how pharmacokinetic/pharmacodynamic (PD) targets can be met with different dosage regimens.
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