Pharmacokinetics and pharmacodynamic target attainment of ceftriaxone in adult severely ill sub-Saharan African patients: a population pharmacokinetic modelling study | Zendy

Jeannet C. Bos | Zendy; Jan M. Prins | Zendy; Mabor C. Mistício | Zendy; Ginto Nunguiane | Zendy; Cláudia N Lang | Zendy; J. Beirão | Zendy; Ron A. A. Mathôt | Zendy; Reinier M. van Hest | Zendy

Open Access

Pharmacokinetics and pharmacodynamic target attainment of ceftriaxone in adult severely ill sub-Saharan African patients: a population pharmacokinetic modelling study

Author(s) -

Jeannet C. Bos,

Jan M. Prins,

Mabor C. Mistício,

Ginto Nunguiane,

Cláudia N Lang,

J. Beirão,

Ron A. A. Mathôt,

Reinier M. van Hest

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky071

Subject(s) - pharmacokinetics , pharmacodynamics , ceftriaxone , medicine , population pharmacokinetics , pharmacology , population , antibiotics , biology , microbiology and biotechnology , environmental health

In sub-Saharan Africa (SSA), the highly albumin-bound β-lactam ceftriaxone is frequently used for the empirical treatment of severe bacterial infections. Systemic drug exposure of β-lactams can be altered in critically ill ICU patients, but pharmacokinetic and pharmacodynamic data for non-ICU SSA populations are lacking.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research