In vitro synergism and anti-biofilm activity of ampicillin, gentamicin, ceftaroline and ceftriaxone against Enterococcus faecalis | Zendy

Lara Thieme | Zendy; Mareike Klinger-Strobel | Zendy; Anita Hartung | Zendy; Claudia Stein | Zendy; Oliwia Makarewicz | Zendy; Mathias W. Pletz | Zendy

Open Access

In vitro synergism and anti-biofilm activity of ampicillin, gentamicin, ceftaroline and ceftriaxone against Enterococcus faecalis

Author(s) -

Lara Thieme,

Mareike Klinger-Strobel,

Anita Hartung,

Claudia Stein,

Oliwia Makarewicz,

Mathias W. Pletz

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky051

Subject(s) - ampicillin , enterococcus faecalis , ceftriaxone , gentamicin , biofilm , microbiology and biotechnology , cephalosporin , antibiotics , enterococcus , biology , bacteria , staphylococcus aureus , genetics

Enterococci frequently cause severe biofilm-associated infections such as endocarditis. The combination of ampicillin/ceftriaxone has recently been clinically evaluated as non-inferior compared with the standard therapy of ampicillin/gentamicin for treatment of Enterococcus faecalis endocarditis. Ceftaroline is a novel cephalosporin with enhanced activity against Gram-positive bacteria.

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