Influence of diluent volume of colistimethate sodium on aerosol characteristics and pharmacokinetics in ventilator-associated pneumonia caused by MDR bacteria | Zendy

Kévin Bihan | Zendy; Noël Zahr | Zendy; M.H. Becquemin | Zendy; Xiao Lü | Zendy; J.F. Bertholon | Zendy; Corinne Vézinet | Zendy; Charlotte Arbelot | Zendy; Antoine Monsel | Zendy; JeanJacques Rouby | Zendy; Olivier Langeron | Zendy; Qin Lü | Zendy

Open Access

Influence of diluent volume of colistimethate sodium on aerosol characteristics and pharmacokinetics in ventilator-associated pneumonia caused by MDR bacteria

Author(s) -

Kévin Bihan,

Noël Zahr,

M.H. Becquemin,

Xiao Lü,

J.F. Bertholon,

Corinne Vézinet,

Charlotte Arbelot,

Antoine Monsel,

JeanJacques Rouby,

Olivier Langeron,

Qin Lü

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky044

Subject(s) - diluent , aerosolization , colistin , nebulizer , dilution , chromatography , chemistry , pharmacokinetics , aerosol , urine , saline , medicine , anesthesia , inhalation , pharmacology , antibiotics , nuclear chemistry , biochemistry , physics , thermodynamics , organic chemistry

Nebulized colistimethate sodium (CMS) can be used to treat ventilator-associated pneumonia caused by MDR bacteria. The influence of the diluent volume of CMS on aerosol delivery has never been studied. The main objectives of the study were to compare aerosol particle characteristics and plasma and urine pharmacokinetics between two diluent volumes in patients treated with nebulized CMS.

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