Transferable vancomycin resistance in clade B commensal-type Enterococcus faecium
Author(s) -
François Lebreton,
Michael D. Valentino,
Katharina Schaufler,
Ashlee M. Earl,
Vincent Cattoir,
Michael S. Gilmore
Publication year - 2018
Publication title -
journal of antimicrobial chemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dky039
Subject(s) - enterococcus faecium , biology , microbiology and biotechnology , clade , vancomycin , plasmid , lineage (genetic) , context (archaeology) , genetics , virology , gene , antibiotics , bacteria , phylogenetics , staphylococcus aureus , paleontology
Vancomycin-resistant Enterococcus faecium is a leading cause of MDR hospital infection. Two genetically definable populations of E. faecium have been identified: hospital-adapted MDR isolates (clade A) and vancomycin-susceptible commensal strains (clade B). VanN-type vancomycin resistance was identified in two isolates of E. faecium recovered from blood and faeces of an immunocompromised patient. To understand the genomic context in which VanN occurred in the hospitalized patient, the risk it posed for transmission in the hospital and its origins, it was of interest to determine where these strains placed within the E. faecium population structure.
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