Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers | Zendy

Tim Felton | Zendy; Kayode Ogungbenro | Zendy; Emmanuel Boselli | Zendy; William Hope | Zendy; Keith A. Rodvold | Zendy

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Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers

Author(s) -

Tim Felton,

Kayode Ogungbenro,

Emmanuel Boselli,

William Hope,

Keith A. Rodvold

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx541

Subject(s) - medicine , piperacillin , critically ill , dosing , antibiotics , population , pharmacodynamics , intensive care , pneumonia , intensive care medicine , pharmacokinetics , genetics , environmental health , bacteria , microbiology and biotechnology , pseudomonas aeruginosa , biology

Severe infections of the respiratory tracts of critically ill patients are common and associated with excess morbidity and mortality. Piperacillin is commonly used to treat pulmonary infections in critically ill patients. Adequate antibiotic concentration in the epithelial lining fluid (ELF) of the lung is essential for successful treatment of pulmonary infection.

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