Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system | Zendy

Keith Poole | Zendy; C. M. Gilmour | Zendy; Maya A. Farha | Zendy; Michael D. Parkins | Zendy; Rachael Klinoski | Zendy; Eric D. Brown | Zendy

Open Access

Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system

Author(s) -

Keith Poole,

C. M. Gilmour,

Maya A. Farha,

Michael D. Parkins,

Rachael Klinoski,

Eric D. Brown

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx539

Subject(s) - efflux , meropenem , pseudomonas aeruginosa , microbiology and biotechnology , aminoglycoside , multiple drug resistance , antibacterial agent , biology , ethidium bromide , pseudomonadaceae , antibiotics , bacteria , antibiotic resistance , biochemistry , genetics , dna

To assess the ability of meropenem to potentiate aminoglycoside (AG) activity against laboratory and AG-resistant cystic fibrosis (CF) isolates of Pseudomonas aeruginosa and to elucidate its mechanism of action.

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