Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa | Zendy

Luzia Holfeld | Zendy; Daniel Knappe | Zendy; Ralf Hoffmann | Zendy

Open Access

Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

Author(s) -

Luzia Holfeld,

Daniel Knappe,

Ralf Hoffmann

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx482

Subject(s) - pseudomonas aeruginosa , enterobacteriaceae , microbiology and biotechnology , antimicrobial , antibiotics , biology , chemistry , bacteria , escherichia coli , biochemistry , genetics , gene

Proline-rich antimicrobial peptides (PrAMPs) represent a promising class of potential therapeutics to treat multiresistant infections. They inhibit bacterial protein translation at the 70S ribosome by either blocking the peptide-exit tunnel (oncocin type) or trapping release factors (apidaecin type).

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