TGF-β-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury | Zendy

Bo Young Jeong | Zendy; Se-Ra Park | Zendy; Sung-Kwon Cho | Zendy; SeongLan Yu | Zendy; Hoi Young Lee | Zendy; Chang Gyo Park | Zendy; Jaeku Kang | Zendy; Da-Young Jung | Zendy; Moon Hyang Park | Zendy; Won-Min Hwang | Zendy; Sung-Ro Yun | Zendy; JuYoung Jung | Zendy; Se-Hee Yoon | Zendy

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TGF-β-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury

Author(s) -

Bo Young Jeong,

Se-Ra Park,

Sung-Kwon Cho,

SeongLan Yu,

Hoi Young Lee,

Chang Gyo Park,

Jaeku Kang,

Da-Young Jung,

Moon Hyang Park,

Won-Min Hwang,

Sung-Ro Yun,

JuYoung Jung,

Se-Hee Yoon

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx479

Subject(s) - colistin , nox4 , acute kidney injury , nephrotoxicity , nicotinamide adenine dinucleotide phosphate , pharmacology , kidney , biology , nadph oxidase , oxidative stress , chemistry , medicine , biochemistry , endocrinology , oxidase test , antibiotics , enzyme

Colistin (polymyxin E) is an important constituent of the polymyxin class of cationic polypeptide antibiotics. Intrarenal oxidative stress can contribute to colistin-induced nephrotoxicity. Nicotinamide adenine dinucleotide 3-phosphate oxidases (Noxs) are important sources of reactive oxygen species. Among the various types of Noxs, Nox4 is predominantly expressed in the kidney.

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