Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs | Zendy

Pierre Gantner | Zendy; Guinevere Q. Lee | Zendy; David Rey | Zendy; Thibault Mésplède | Zendy; Marialuisa Partisani | Zendy; Christine Cheneau | Zendy; Geneviève Beck-Wirth | Zendy; J Faller | Zendy; M. Mohseni-Zadeh | Zendy; M. Martinot | Zendy; Mark A. Wainberg | Zendy; Samira FafiKremer | Zendy

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Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs

Author(s) -

Pierre Gantner,

Guinevere Q. Lee,

David Rey,

Thibault Mésplède,

Marialuisa Partisani,

Christine Cheneau,

Geneviève Beck-Wirth,

J Faller,

M. Mohseni-Zadeh,

M. Martinot,

Mark A. Wainberg,

Samira FafiKremer

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx475

Subject(s) - dolutegravir , human immunodeficiency virus (hiv) , virology , genetic diversity , biology , genetics , medicine , antiretroviral therapy , environmental health , viral load , population

Better understanding of the dynamics of HIV reservoirs under ART is a critical step to achieve a functional HIV cure. Our objective was to assess the genetic diversity of archived HIV-1 DNA over 48 weeks in blood cells of individuals starting treatment with a dolutegravir-based regimen.

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