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Prevalence of carbapenem resistance and carbapenemase production among Enterobacteriaceae isolated from urine in the UK: results of the UK infection-Carbapenem Resistance Evaluation Surveillance Trial (iCREST-UK)
Author(s) -
Neil Woodford,
Li Xu-McCrae,
Shazad Mushtaq,
Houdini H.T. Wu,
Matthew J. Ellington,
Owen Lancaster,
Frances Davies,
Hugo Donaldson,
G. Gopal Rao,
Anita Verma,
David W. Wareham,
Holly Ciesielczuk,
Gregory G. Stone,
Paurus Irani,
Simon Bracher,
Peter M. Hawkey
Publication year - 2017
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkx471
Subject(s) - carbapenem , carbapenem resistant enterobacteriaceae , enterobacteriaceae , microbiology and biotechnology , enterobacteriaceae infections , urine , biology , medicine , antibiotics , escherichia coli , gene , biochemistry
Although carbapenem susceptibility testing has been recommended for all Enterobacteriaceae from clinical specimens, for practical reasons a carbapenem is not included in many primary antibiotic panels for urine specimens. The 'iCREST' study sought carbapenemase-producing Enterobacteriaceae (CPE) in routine urine specimens yielding Gram-negative growth in five diagnostic laboratories in the UK. We sought also to compare locally and centrally determined MICs of meropenem and ceftazidime/avibactam.

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