Delivering precision antimicrobial therapy through closed-loop control systems | Zendy

Timothy M. Rawson | Zendy; Dermot O’Hare | Zendy; Pau Herrero | Zendy; Sanjiv Sharma | Zendy; Luke Moore | Zendy; Eoghan de Barra | Zendy; Jason A. Roberts | Zendy; Anthony Gordon | Zendy; William Hope | Zendy; Pantelis Georgiou | Zendy; Anthony E. G. Cass | Zendy; Alison Holmes | Zendy

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Delivering precision antimicrobial therapy through closed-loop control systems

Author(s) -

Timothy M. Rawson,

Dermot O’Hare,

Pau Herrero,

Sanjiv Sharma,

Luke Moore,

Eoghan de Barra,

Jason A. Roberts,

Anthony Gordon,

William Hope,

Pantelis Georgiou,

Anthony E. G. Cass,

Alison Holmes

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx458

Subject(s) - antimicrobial , antimicrobial drug , closed loop , intensive care medicine , therapeutic drug monitoring , antibiotic resistance , medicine , drug resistance , risk analysis (engineering) , biochemical engineering , drug , biomedical engineering , computer science , medical physics , pharmacology , antibiotics , control engineering , engineering , biology , microbiology and biotechnology

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.

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