Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model | Zendy

Iain J. Abbott | Zendy; Joseph Meletiadis | Zendy; Imane Belghanch | Zendy; Rixt A. Wijma | Zendy; Lamprini Kanioura | Zendy; Jason A. Roberts | Zendy; Anton Y. Peleg | Zendy; Johan W. Mouton | Zendy

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Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model

Author(s) -

Iain J. Abbott,

Joseph Meletiadis,

Imane Belghanch,

Rixt A. Wijma,

Lamprini Kanioura,

Jason A. Roberts,

Anton Y. Peleg,

Johan W. Mouton

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx441

Subject(s) - fosfomycin , microbiology and biotechnology , klebsiella pneumoniae , enterobacter cloacae , pharmacodynamics , population , enterobacteriaceae , antibiotics , urinary system , biology , pharmacokinetics , medicine , escherichia coli , pharmacology , biochemistry , environmental health , gene

Urinary tract infections (UTIs) are among the most common bacterial infections and a frequent indication for antibiotic use. Fosfomycin, an important oral antibiotic for outpatient UTIs, remains a viable option for MDR uropathogens. We aimed to perform pharmacodynamic profiling simulating urinary concentrations to assess the adequacy of the current dosing regimen.

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