Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass | Zendy

Divna Calic | Zendy; Robert E. Ariano | Zendy; Rakesh C. Arora | Zendy; Hilary P. Grocott | Zendy; Ted M. Lakowski | Zendy; L. Ryan | Zendy; Sheryl Zelenitsky | Zendy

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Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass

Author(s) -

Divna Calic,

Robert E. Ariano,

Rakesh C. Arora,

Hilary P. Grocott,

Ted M. Lakowski,

L. Ryan,

Sheryl Zelenitsky

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx439

Subject(s) - cefazolin , medicine , anesthesia , cardiac surgery , cardiopulmonary bypass , dosing , surgery , regimen , antibiotic prophylaxis , antibiotics , chemistry , biochemistry

Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether adequate concentrations are achieved in this patient population. The goal of our study was to characterize intraoperative cefazolin concentrations particularly at wound closure with regards to maintaining target cefazolin closure concentrations ≥40 mg/L.

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