Effect of Staphylococcus aureus Tet38 native efflux pump on in vivo response to tetracycline in a murine subcutaneous abscess model | Zendy

Chunhui Chen | Zendy; David C. Hooper | Zendy

Open Access

Effect of Staphylococcus aureus Tet38 native efflux pump on in vivo response to tetracycline in a murine subcutaneous abscess model

Author(s) -

Chunhui Chen,

David C. Hooper

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx432

Subject(s) - tetracycline , staphylococcus aureus , microbiology and biotechnology , in vivo , efflux , antibiotics , subcutaneous abscess , abscess , mutant , subcutaneous injection , antibacterial agent , chemistry , bacteria , biology , medicine , surgery , biochemistry , genetics , gene , bioinformatics

Staphylococcus aureus native efflux pump Tet38 confers resistance to tetracycline when overexpressed. tet38 expression is selectively upregulated in infection sites. This study evaluated the effect of Tet38 on tetracycline response in a murine subcutaneous abscess model.

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