Comparative efficacy of drugs for treating giardiasis: a systematic update of the literature and network meta-analysis of randomized clinical trials | Zendy

José M. OrdóñezMena | Zendy; Noel McCarthy | Zendy; Thomas Fanshawe | Zendy

Open Access

Comparative efficacy of drugs for treating giardiasis: a systematic update of the literature and network meta-analysis of randomized clinical trials

Author(s) -

José M. OrdóñezMena,

Noel McCarthy,

Thomas Fanshawe

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx430

Subject(s) - tinidazole , metronidazole , randomized controlled trial , medicine , systematic review , meta analysis , medline , surgery , biology , antibiotics , biochemistry , microbiology and biotechnology

Giardiasis is the commonest intestinal protozoal infection worldwide. The current first-choice therapy is metronidazole. Recently, other drugs with potentially higher efficacy or with fewer and milder side effects have increased in popularity, but evidence is limited by a scarcity of randomized controlled trials (RCTs) comparing the many treatment options available. Network meta-analysis (NMA) is a useful tool to compare multiple treatments when there is limited or no direct evidence available.

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