Bacterial zincophore [S,S]-ethylenediamine-N,N′-disuccinic acid is an effective inhibitor of MBLs | Zendy

Anna Proschak | Zendy; Jan S. Kramer | Zendy; Ewgenij Proschak | Zendy; Thomas A. Wichelhaus | Zendy

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Bacterial zincophore [S,S]-ethylenediamine-N,N′-disuccinic acid is an effective inhibitor of MBLs

Author(s) -

Anna Proschak,

Jan S. Kramer,

Ewgenij Proschak,

Thomas A. Wichelhaus

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx403

Subject(s) - imipenem , edds , microbiology and biotechnology , ertapenem , klebsiella pneumoniae , in vivo , biology , pharmacology , chemistry , antibiotics , biochemistry , escherichia coli , antibiotic resistance , ecology , contamination , soil contamination , gene

Carbapenemases such as MBLs are spreading among Gram-negative bacterial pathogens. Infections due to these MDR bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase-producing bacteria include β-lactamase inhibitor combinations. [S,S]-ethylenediamine-N,N'-disuccinic acid (EDDS) is a chelator and potential inhibitor of MBLs. We investigated the activity of EDDS in combination with imipenem against MBL-producing bacteria in vitro as well as in vivo.

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