Open AccessHighly variable absorption of clavulanic acid during the day: a population pharmacokinetic analysis
Author(s) -
Femke de Velde,
Brenda C. M. de Winter,
Birgit C. P. Koch,
Teun van Gelder,
Johan W. Mouton
Publication year - 2017
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkx376
Subject(s) - pharmacokinetics , cmax , population , nonmem , clavulanic acid , medicine , morning , dosing , bioavailability , amoxicillin , pharmacology , chemistry , antibiotics , biochemistry , environmental health
To calculate the clavulanic acid exposure of oral amoxicillin/clavulanic acid dosing regimens, to investigate variability using a population pharmacokinetic model and to explore target attainment using Monte Carlo simulations.
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