Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance | Zendy

Juan-Carlos Jiménez-Castellanos | Zendy; Wan Ahmad Kamil Wan Nur Ismah | Zendy; Yuiko Takebayashi | Zendy; Jacqueline Findlay | Zendy; Thamarai Schneiders | Zendy; Kate J. Heesom | Zendy; Matthew B. Avison | Zendy

Open Access

Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance

Author(s) -

Juan-Carlos Jiménez-Castellanos,

Wan Ahmad Kamil Wan Nur Ismah,

Yuiko Takebayashi,

Jacqueline Findlay,

Thamarai Schneiders,

Kate J. Heesom,

Matthew B. Avison

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx345

Subject(s) - overproduction , klebsiella pneumoniae , efflux , microbiology and biotechnology , proteome , biology , chemistry , biochemistry , gene , escherichia coli

In Klebsiella pneumoniae, overproduction of RamA results in reduced envelope permeability and reduced antimicrobial susceptibility but clinically relevant resistance is rarely observed. Here we have tested whether RamA overproduction can enhance acquired β-lactam resistance mechanisms in K. pneumoniae and have defined the envelope protein abundance changes upon RamA overproduction during growth in low and high osmolarity media.

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