Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors | Zendy

MingTain Lai | Zendy; Paul Tawa | Zendy; Anick Auger | Zendy; Deping Wang | Zendy; Hua-Poo Su | Zendy; Youwei Yan | Zendy; Daria J. Hazuda | Zendy; Michael D. Miller | Zendy; Ernest AsanteAppiah | Zendy; Roman A. Melnyk | Zendy

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Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors

Author(s) -

MingTain Lai,

Paul Tawa,

Anick Auger,

Deping Wang,

Hua-Poo Su,

Youwei Yan,

Daria J. Hazuda,

Michael D. Miller,

Ernest AsanteAppiah,

Roman A. Melnyk

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx332

Subject(s) - reverse transcriptase , binding site , nucleotidyltransferase , resistance mutation , primer (cosmetics) , mutant , biology , chemistry , mutation , enzyme , potency , virology , primer binding site , in vitro , microbiology and biotechnology , biochemistry , rna , organic chemistry , gene

The increasing prevalence of mutations in HIV-1 reverse transcriptase (RT) that confer resistance to existing NRTIs and NNRTIs underscores the need to develop RT inhibitors with novel mode-of-inhibition and distinct resistance profiles.

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