Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients | Zendy

Katrien Forier | Zendy; Virginie Van Heck | Zendy; Mieke Carlier | Zendy; Eva Van Braeckel | Zendy; Sabine Van daele | Zendy; Frans De Baets | Zendy; Petra Schelstraete | Zendy; Filomeen Haerynck | Zendy; Veronique Stove | Zendy; Leen Van Simaey | Zendy; Mario Vaneechoutte | Zendy; Alain Verstraete | Zendy

Open Access

Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients

Author(s) -

Katrien Forier,

Virginie Van Heck,

Mieke Carlier,

Eva Van Braeckel,

Sabine Van daele,

Frans De Baets,

Petra Schelstraete,

Filomeen Haerynck,

Veronique Stove,

Leen Van Simaey,

Mario Vaneechoutte,

Alain Verstraete

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx331

Subject(s) - piperacillin , aztreonam , sputum , antibiotics , ceftazidime , cystic fibrosis , medicine , chromatography , chemistry , microbiology and biotechnology , pathology , antibiotic resistance , tuberculosis , pseudomonas aeruginosa , biology , bacteria , imipenem , genetics

Antibiotic therapy is of vital importance for the control of infectious exacerbations in cystic fibrosis (CF) patients. However, very little is known regarding the fraction of systemically administered antibiotics reaching the lower respiratory tract secretions. We developed and validated a method to measure the concentrations of piperacillin, ceftazidime, meropenem and aztreonam in CF sputum, and present the validation data.

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