Open AccessIdentification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis
Author(s) -
Jiazhen Chen,
Shuo Zhang,
Peng Cui,
Wanliang Shi,
Wenhong Zhang,
Ying Zhang
Publication year - 2017
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkx316
Subject(s) - cycloserine , biology , mutant , genetics , mycobacterium tuberculosis , microbiology and biotechnology , mutation , gene , tuberculosis , medicine , antibiotics , pathology
d-Cycloserine is an important second-line drug used to treat MDR- and XDR-TB. However, the mechanisms of resistance to d-cycloserine are not well understood. Here we investigated the molecular basis of d-cycloserine resistance using in vitro-isolated resistant mutants.
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