A programme to create short-course chemotherapy for pulmonary Mycobacterium avium disease based on pharmacokinetics/pharmacodynamics and mathematical forecasting | Zendy

Devyani Deshpande | Zendy; Shashikant Srivastava | Zendy; Tawanda Gumbo | Zendy

Open Access

A programme to create short-course chemotherapy for pulmonary Mycobacterium avium disease based on pharmacokinetics/pharmacodynamics and mathematical forecasting

Author(s) -

Devyani Deshpande,

Shashikant Srivastava,

Tawanda Gumbo

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx309

Subject(s) - medicine , pharmacokinetics , pharmacodynamics , regimen , repurposing , pharmacology , antibiotics , intensive care medicine , biology , microbiology and biotechnology , ecology

Pulmonary Mycobacterium avium complex (MAC) prevalence is on the rise worldwide. The average therapy duration is 1.5 years, which is associated with poor cure rates. Our objective was to develop a programme to design a combination therapy regimen for pulmonary MAC to be administered for 6 months or less with efficacy in > 90% of patients.

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