Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE | Zendy

Alexandros Lazaris | Zendy; David C. Coleman | Zendy; Angela Kearns | Zendy; Bruno Pichon | Zendy; Peter M. Kinnevey | Zendy; Megan R. Earls | Zendy; Breida Boyle | Zendy; Brian O’Connell | Zendy; Gráinne I. Brennan | Zendy; Anna C. Shore | Zendy

Open Access

Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE

Author(s) -

Alexandros Lazaris,

David C. Coleman,

Angela Kearns,

Bruno Pichon,

Peter M. Kinnevey,

Megan R. Earls,

Breida Boyle,

Brian O’Connell,

Gráinne I. Brennan,

Anna C. Shore

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx292

Subject(s) - linezolid , enterococcus faecium , staphylococcus epidermidis , microbiology and biotechnology , outbreak , medicine , vancomycin resistant enterococcus , enterococcus , vancomycin , methicillin resistant staphylococcus aureus , biology , staphylococcus aureus , virology , antibiotics , bacteria , genetics

Linezolid is often the drug of last resort to treat infections caused by Gram-positive cocci. Linezolid resistance can be mutational (23S rRNA or L-protein) or, less commonly, acquired [predominantly cfr, conferring resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A compounds (PhLOPSA) or optrA, encoding oxazolidinone and phenicol resistance].

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