Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms | Zendy

Janus A. J. Haagensen | Zendy; Davide Verotta | Zendy; Liusheng Huang | Zendy; Joanne N. Engel | Zendy; Alfred M. Spormann | Zendy; Katherine Yang | Zendy

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Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms

Author(s) -

Janus A. J. Haagensen,

Davide Verotta,

Liusheng Huang,

Joanne N. Engel,

Alfred M. Spormann,

Katherine Yang

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx288

Subject(s) - tobramycin , meropenem , biofilm , pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , pharmacokinetics , biology , pharmacodynamics , pharmacology , chemistry , bacteria , antibiotic resistance , gentamicin , genetics

The selection and dose of antibiotic therapy for biofilm-related infections are based on traditional pharmacokinetic studies using planktonic bacteria. The objective of this study was to characterize the time course and spatial activity of human exposure levels of meropenem and tobramycin against Pseudomonas aeruginosa biofilms grown in an in vitro flow-chamber model.

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