Effect of β-lactamase production and β-lactam instability on MIC testing results for Mycobacterium abscessus | Zendy

Anna Rominski | Zendy; Bettina Schulthess | Zendy; Daniel M. Müller | Zendy; Peter M. Keller | Zendy; Peter Sander | Zendy

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Effect of β-lactamase production and β-lactam instability on MIC testing results for Mycobacterium abscessus

Author(s) -

Anna Rominski,

Bettina Schulthess,

Daniel M. Müller,

Peter M. Keller,

Peter Sander

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx284

Subject(s) - cefoxitin , meropenem , imipenem , microbiology and biotechnology , mycobacterium abscessus , carbapenem , antibiotics , medicine , mycobacterium , biology , antibiotic resistance , bacteria , pathology , genetics , tuberculosis , staphylococcus aureus

Limited treatment options available for Mycobacterium abscessus infections include the parenteral β-lactam antibiotics cefoxitin and imipenem, which show moderate in vitro activity. Other β-lactam antibiotics (except meropenem) have no considerable in vitro activity, due to their rapid hydrolysis by a broad-spectrum β-lactamase (Bla_Mab). We here addressed the impact of β-lactamase production and β-lactam in vitro stability on M. abscessus MIC results and determined the epidemiological cut-off (ECOFF) values of cefoxitin, imipenem and meropenem.

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