Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents | Zendy

Donelly A. van Schalkwyk | Zendy; Robert W. Moon | Zendy; Benjamin Blasco | Zendy; Colin J. Sutherland | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents

Author(s) -

Donelly A. van Schalkwyk,

Robert W. Moon,

Benjamin Blasco,

Colin J. Sutherland

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx279

Subject(s) - plasmodium knowlesi , plasmodium falciparum , virology , malaria , antimalarial agent , plasmodium (life cycle) , biology , microbiology and biotechnology , immunology , parasite hosting , plasmodium vivax , world wide web , computer science

The simian malaria parasite Plasmodium knowlesi is now a well-recognized pathogen of humans in South-East Asia. Clinical infections appear adequately treated with existing drug regimens, but the evidence base for this practice remains weak. The availability of P. knowlesi cultures adapted to continuous propagation in human erythrocytes enables specific studies of in vitro susceptibility of the species to antimalarial agents, and could provide a surrogate system for testing investigational compounds against Plasmodium vivax and other non-Plasmodium falciparum infections that cannot currently be propagated in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research