Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data | Zendy

Elisabet I. Nielsen | Zendy; David D. Khan | Zendy; Sha Cao | Zendy; Ulrika Lustig | Zendy; Diarmaid Hughes | Zendy; Dan I. Andersson | Zendy; Lena E. Friberg | Zendy

Open Access

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data

Author(s) -

Elisabet I. Nielsen,

David D. Khan,

Sha Cao,

Ulrika Lustig,

Diarmaid Hughes,

Dan I. Andersson,

Lena E. Friberg

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx269

Subject(s) - pharmacodynamics , pharmacokinetics , pharmacology , in vitro , medicine , biology , biochemistry

Pharmacokinetic/pharmacodynamic (PKPD) models developed based on data from in vitro time-kill experiments have been suggested to contribute to more efficient drug development programmes and better dosing strategies for antibiotics. However, for satisfactory predictions such models would have to show good extrapolation properties.

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