Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli | Zendy

MinhDuy Phan | Zendy; Nguyen Thi Khanh Nhu | Zendy; Maud E. S. Achard | Zendy; Brian M. Forde | Zendy; KarWai Hong | Zendy; Teik Min Chong | Zendy; WaiFong Yin | Zendy; KokGan Chan | Zendy; Nicholas P. West | Zendy; Mark J. Walker | Zendy; David L. Paterson | Zendy; Scott A. Beatson | Zendy; Mark A. Schembri | Zendy

Open Access

Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli

Author(s) -

MinhDuy Phan,

Nguyen Thi Khanh Nhu,

Maud E. S. Achard,

Brian M. Forde,

KarWai Hong,

Teik Min Chong,

WaiFong Yin,

KokGan Chan,

Nicholas P. West,

Mark J. Walker,

David L. Paterson,

Scott A. Beatson,

Mark A. Schembri

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx204

Subject(s) - colistin , polymyxin , transposon mutagenesis , biology , transposable element , polymyxin b , escherichia coli , genetics , microbiology and biotechnology , mutagenesis , plasmid , gene , mutant , bacteria , antibiotics

Polymyxins remain one of the last-resort drugs to treat infections caused by MDR Gram-negative pathogens. Here, we determined the mechanisms by which chromosomally encoded resistance to colistin and polymyxin B can arise in the MDR uropathogenic Escherichia coli ST131 reference strain EC958.

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