Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics | Zendy

Hélène Scornec | Zendy; Xavier Bellanger | Zendy; Hélène Guilloteau | Zendy; Guillaume Groshenry | Zendy; Christophe Merlin | Zendy

Open Access

Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics

Author(s) -

Hélène Scornec,

Xavier Bellanger,

Hélène Guilloteau,

Guillaume Groshenry,

Christophe Merlin

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx202

Subject(s) - enterococcus faecalis , antibiotics , microbiology and biotechnology , enterococcus , biology , bacteria , staphylococcus aureus , genetics

Some antibiotics induce the dissemination of their own resistance genes by interfering with the regulation of specific mobile genetic elements. In Tn916, subinhibitory concentrations of tetracycline activate the transfer of the element through an anti-attenuation mechanism that relies on the Tet(M) resistance protein, itself encoded by the element.

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