Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan | Zendy

Mark Webber | Zendy; Michelle M. C. Buckner | Zendy; Liam Stephen Redgrave | Zendy; Gyles Ifill | Zendy; Lesley A. Mitchenall | Zendy; Carly Webb | Zendy; Robyn Iddles | Zendy; Anthony Maxwell | Zendy; Laura J. V. Piddock | Zendy

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Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan

Author(s) -

Mark Webber,

Michelle M. C. Buckner,

Liam Stephen Redgrave,

Gyles Ifill,

Lesley A. Mitchenall,

Carly Webb,

Robyn Iddles,

Anthony Maxwell,

Laura J. V. Piddock

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx201

Subject(s) - dna gyrase , triclosan , quinolone , rpon , microbiology and biotechnology , salmonella enterica , dna supercoil , mutant , escherichia coli , biology , rpos , salmonella , genetics , bacteria , antibiotics , dna , gene , promoter , medicine , gene expression , pathology , dna replication

Cross-resistance between antibiotics and biocides is a potentially important driver of MDR. A relationship between susceptibility of Salmonella to quinolones and triclosan has been observed. This study aimed to: (i) investigate the mechanism underpinning this; (ii) determine whether the phenotype is conserved in Escherichia coli; and (iii) evaluate the potential for triclosan to select for quinolone resistance.

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