Open AccessDarunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir
Author(s) -
Hanni Bartels,
Laurent A. Décosterd,
Manuel Battegay,
Catia Marzolini
Publication year - 2017
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkx165
Subject(s) - cobicistat , ritonavir , darunavir , pharmacology , medicine , regimen , virology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
Cobicistat and ritonavir have different inhibitory profiles for drug transporters that could impact the distribution of co-administered drugs. We compared darunavir concentrations in CSF when boosted by cobicistat versus ritonavir relative to plasma concentrations and with WT HIV-1 IC50 and IC90.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom