Development of carbapenem resistance in Pseudomonas aeruginosa is associated with OprD polymorphisms, particularly the amino acid substitution at codon 170 | Zendy

JwuChing Shu | Zendy; An-Jing Kuo | Zendy; LinHui Su | Zendy; Tsui-Ping Liu | Zendy; MingHsun Lee | Zendy; I-Ning Su | Zendy; TsuLan Wu | Zendy

Open Access

Development of carbapenem resistance in Pseudomonas aeruginosa is associated with OprD polymorphisms, particularly the amino acid substitution at codon 170

Author(s) -

JwuChing Shu,

An-Jing Kuo,

LinHui Su,

Tsui-Ping Liu,

MingHsun Lee,

I-Ning Su,

TsuLan Wu

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx158

Subject(s) - pseudomonas aeruginosa , carbapenem , biology , etest , imipenem , microbiology and biotechnology , mutant , allele , genetics , gene , bacteria , antibiotics

Pan-susceptible Pseudomonas aeruginosa (PSPA) clinical isolates carrying an OprD with loop 7 shortening (the group-1A allele) were found to rapidly develop carbapenem resistance under continuous selection pressure. We further studied whether OprD polymorphisms are associated with the potential to develop carbapenem resistance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research