The complete nucleotide sequence of an IncP-2 megaplasmid unveils a mosaic architecture comprising a putative novel blaVIM-2-harbouring transposon in Pseudomonas aeruginosa | Zendy

João Botelho | Zendy; Filipa Grosso | Zendy; Sandra Quinteira | Zendy; Aymen Mabrouk | Zendy; Luı́sa Peixe | Zendy

Open Access

The complete nucleotide sequence of an IncP-2 megaplasmid unveils a mosaic architecture comprising a putative novel blaVIM-2-harbouring transposon in Pseudomonas aeruginosa

Author(s) -

João Botelho,

Filipa Grosso,

Sandra Quinteira,

Aymen Mabrouk,

Luı́sa Peixe

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx143

Subject(s) - transposable element , integron , plasmid , transposase , biology , insertion sequence , genetics , pseudomonas aeruginosa , operon , mobile genetic elements , gene , virulence , microbiology and biotechnology , transposon mutagenesis , genomic island , mutant , bacteria

In Pseudomonas aeruginosa , bla VIM-2 has been mostly associated with a chromosomal location and rarely with a plasmid backbone. Until now, only three complete bla VIM-2 -carrying plasmid sequences have been described in this species. Here we explore the modular structure of pJB37, the first bla VIM-2 -carrying megaplasmid described in P. aeruginosa .

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