Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs) | Zendy

Juwon Yim | Zendy; Jordan R. Smith | Zendy; Nivedita B. Singh | Zendy; Seth Rice | Zendy; Kyle Stamper | Zendy; Cristina García de la Mària | Zendy; Arnold S. Bayer | Zendy; Nagendra N. Mishra | Zendy; José M. Miró | Zendy; Truc T. Tran | Zendy; César A. Arias | Zendy; Paul M. Sullam | Zendy; Michael J. Rybak | Zendy

Open Access

Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs)

Author(s) -

Juwon Yim,

Jordan R. Smith,

Nivedita B. Singh,

Seth Rice,

Kyle Stamper,

Cristina García de la Mària,

Arnold S. Bayer,

Nagendra N. Mishra,

José M. Miró,

Truc T. Tran,

César A. Arias,

Paul M. Sullam,

Michael J. Rybak

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx130

Subject(s) - daptomycin , streptococcus mitis , gentamicin , ceftriaxone , microbiology and biotechnology , antibiotics , penicillin , endocarditis , cephalosporin , streptococcus , medicine , pharmacology , vancomycin , biology , bacteria , staphylococcus aureus , genetics

Among viridans group streptococcal infective endocarditis (IE), the Streptococcus mitis group is the most common aetiological organism. Treatment of IE caused by the S. mitis group is challenging due to the high frequency of β-lactam resistance, drug allergy and intolerability of mainstay antimicrobial agents such as vancomycin or gentamicin. Daptomycin has been suggested as an alternative therapeutic option in these scenarios based on its excellent susceptibility profile against S. mitis group strains . However, the propensity of many S. mitis group strains to rapidly evolve stable, high-level daptomycin resistance potentially limits this approach.

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