Antiretroviral-treated HIV-1 patients can harbour resistant viruses in CSF despite an undetectable viral load in plasma | Zendy

Cathia Soulié | Zendy; Maxime Grudé | Zendy; Diane Descamps | Zendy; Corinne Amiel | Zendy; Laurence MorandJoubert | Zendy; Stéphanie Raymond | Zendy; Coralie Pallier | Zendy; Pantxika Bellecave | Zendy; Sandrine Reigadas | Zendy; MaryAnne Trabaud | Zendy; Constance Delaugerre | Zendy; Brigitte Montès | Zendy; Francis Barin | Zendy; Virginie Ferré | Zendy; Hélène Jeulin | Zendy; Chakib Alloui | Zendy; Sabine Yerly | Zendy; Anne Signori-Schmück | Zendy; Aurélie Guigon | Zendy; Samira FafiKremer | Zendy; Stéphanie HaïmBoukobza | Zendy; Audrey Mirand | Zendy; Anne Maillard | Zendy; Sophie Vallet | Zendy; Catherine Roussel | Zendy; Lambert Assoumou | Zendy; Vincent Cálvez | Zendy; Philippe Flandre | Zendy; AnneGeneviève Marcelin | Zendy

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Antiretroviral-treated HIV-1 patients can harbour resistant viruses in CSF despite an undetectable viral load in plasma

Author(s) -

Cathia Soulié,

Maxime Grudé,

Diane Descamps,

Corinne Amiel,

Laurence MorandJoubert,

Stéphanie Raymond,

Coralie Pallier,

Pantxika Bellecave,

Sandrine Reigadas,

MaryAnne Trabaud,

Constance Delaugerre,

Brigitte Montès,

Francis Barin,

Virginie Ferré,

Hélène Jeulin,

Chakib Alloui,

Sabine Yerly,

Anne Signori-Schmück,

Aurélie Guigon,

Samira FafiKremer,

Stéphanie HaïmBoukobza,

Audrey Mirand,

Anne Maillard,

Sophie Vallet,

Catherine Roussel,

Lambert Assoumou,

Vincent Cálvez,

Philippe Flandre,

AnneGeneviève Marcelin

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx128

Subject(s) - viral load , medicine , genotype , lentivirus , sida , virology , human immunodeficiency virus (hiv) , population , antiretroviral therapy , immunology , viral disease , gastroenterology , biology , biochemistry , environmental health , gene

HIV therapy reduces the CSF HIV RNA viral load (VL) and prevents disorders related to HIV encephalitis. However, these brain disorders may persist in some cases. A large population of antiretroviral-treated patients who had a VL > 1.7 log 10 copies/mL in CSF with detectable or undetectable VL in plasma associated with cognitive impairment was studied, in order to characterize discriminatory factors of these two patient populations.

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