Elucidation of Mycobacterium abscessus aminoglycoside and capreomycin resistance by targeted deletion of three putative resistance genes | Zendy

Anna Rominski | Zendy; Petra Selchow | Zendy; Katja Becker | Zendy; Juliane K. Brülle | Zendy; Michael Dal Molin | Zendy; Peter Sander | Zendy

Open Access

Elucidation of Mycobacterium abscessus aminoglycoside and capreomycin resistance by targeted deletion of three putative resistance genes

Author(s) -

Anna Rominski,

Petra Selchow,

Katja Becker,

Juliane K. Brülle,

Michael Dal Molin,

Peter Sander

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx125

Subject(s) - capreomycin , mycobacterium abscessus , kanamycin , aminoglycoside , microbiology and biotechnology , hygromycin b , amikacin , biology , drug resistance , antibiotics , mycobacterium , mutant , gene , genetics , rifampicin , bacteria , ethambutol

Mycobacterium abscessus is innately resistant to a variety of drugs thereby limiting therapeutic options. Bacterial resistance to aminoglycosides (AGs) is conferred mainly by AG-modifying enzymes, which often have overlapping activities. Several putative AG-modifying enzymes are encoded in the genome of M. abscessus . The aim of this study was to investigate the molecular basis underlying AG resistance in M. abscessus .

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