Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli | Zendy

Nicholas M. Smith | Zendy; Zackery P. Bulman | Zendy; Arthur O. Sieron | Zendy; Jürgen B. Bulitta | Zendy; Patricia N. Holden | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy; Gerard D. Wright | Zendy; Brian T. Tsuji | Zendy

Open Access

Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli

Author(s) -

Nicholas M. Smith,

Zackery P. Bulman,

Arthur O. Sieron,

Jürgen B. Bulitta,

Patricia N. Holden,

Roger L. Nation,

Jian Li,

Gerard D. Wright,

Brian T. Tsuji

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx121

Subject(s) - polymyxin , polymyxin b , microbiology and biotechnology , escherichia coli , antibiotics , biology , enterobacteriaceae , chemistry , biochemistry , gene

Gram-negative bacteria harbouring the mcr-1 plasmid are resistant to the 'last-line' polymyxins and have been reported worldwide. Our objective was to define the impact of increasing the initial polymyxin B dose intensity against an mcr-1 -harbouring strain to delineate the impact of plasmid-mediated polymyxin resistance on the dynamics of bacterial killing and resistance.

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