An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs | Zendy

Erasmus Smit | Zendy; Ellen White | Zendy; Duncan A. Clark | Zendy; Duncan Churchill | Zendy; Hongyi Zhang | Zendy; Simon Collins | Zendy; Deenan Pillay | Zendy; Caroline Sabin | Zendy; Mark Nelson | Zendy; Alan Winston | Zendy; Sophie José | Zendy; Anna Tostevin | Zendy; David Dunn | Zendy

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An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs

Author(s) -

Erasmus Smit,

Ellen White,

Duncan A. Clark,

Duncan Churchill,

Hongyi Zhang,

Simon Collins,

Deenan Pillay,

Caroline Sabin,

Mark Nelson,

Alan Winston,

Sophie José,

Anna Tostevin,

David Dunn

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx091

Subject(s) - human immunodeficiency virus (hiv) , virology , medicine , didanosine , sida , viral disease

HIV-1 subtype C might have a greater propensity to develop K65R mutations in patients with virological failure compared with other subtypes. However, the strong association between viral subtype and confounding factors such as exposure groups and ethnicity affects the calculation of this propensity. We exploited the diversity of viral subtypes within the UK to undertake a direct comparative analysis.

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