Pharmacodynamics of colistin and fosfomycin: a ‘treasure trove’ combination combats KPC-producing Klebsiella pneumoniae | Zendy

Miao Zhao | Zendy; Zackery P. Bulman | Zendy; Justin R. Lenhard | Zendy; Michael J. Satlin | Zendy; Barry N. Kreiswirth | Zendy; Thomas J. Walsh | Zendy; Amanda Marrocco | Zendy; Phillip J. Bergen | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy; Jing Zhang | Zendy; Brian T. Tsuji | Zendy

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Pharmacodynamics of colistin and fosfomycin: a ‘treasure trove’ combination combats KPC-producing Klebsiella pneumoniae

Author(s) -

Miao Zhao,

Zackery P. Bulman,

Justin R. Lenhard,

Michael J. Satlin,

Barry N. Kreiswirth,

Thomas J. Walsh,

Amanda Marrocco,

Phillip J. Bergen,

Roger L. Nation,

Jian Li,

Jing Zhang,

Brian T. Tsuji

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx070

Subject(s) - fosfomycin , colistin , klebsiella pneumoniae , pharmacodynamics , microbiology and biotechnology , antibiotics , pharmacology , medicine , biology , pharmacokinetics , escherichia coli , biochemistry , gene

KPC-producing Klebsiella pneumoniae are an emerging public health problem around the globe. We defined the combinatorial pharmacodynamics and ability to suppress resistance of two 'old' antibiotics, fosfomycin and colistin, in time-kill experiments and hollow-fibre infection models (HFIM).

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