Dihydroorotate dehydrogenase inhibitor F901318 has potent in vitro activity against Scedosporium species and Lomentospora prolificans | Zendy

Nathan P. Wiederhold | Zendy; Derek Law | Zendy; Michael Birch | Zendy

Open Access

Dihydroorotate dehydrogenase inhibitor F901318 has potent in vitro activity against Scedosporium species and Lomentospora prolificans

Author(s) -

Nathan P. Wiederhold,

Derek Law,

Michael Birch

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx065

Subject(s) - posaconazole , scedosporium apiospermum , caspofungin , voriconazole , microbiology and biotechnology , amphotericin b , biology , terbinafine , pharmacology , itraconazole , antifungal

Scedosporium species and Lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. Our objective was to assess the in vitro potency of F901318, a member of the orotomide class of antifungals, against Scedosporium species and L. prolificans .

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