Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting | Zendy

Patrick Musicha | Zendy; Nicholas Feasey | Zendy; Amy K. Cain | Zendy; Teemu Kallonen | Zendy; Chrispin Chaguza | Zendy; Chikondi Peno | Zendy; Margaret Khonga | Zendy; Sarah Thompson | Zendy; Katherine J. Gray | Zendy; Alison E. Mather | Zendy; Robert S. Heyderman | Zendy; Dean Everett | Zendy; Nicholas R. Thomson | Zendy; Chisomo Msefula | Zendy

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Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting

Author(s) -

Patrick Musicha,

Nicholas Feasey,

Amy K. Cain,

Teemu Kallonen,

Chrispin Chaguza,

Chikondi Peno,

Margaret Khonga,

Sarah Thompson,

Katherine J. Gray,

Alison E. Mather,

Robert S. Heyderman,

Dean Everett,

Nicholas R. Thomson,

Chisomo Msefula

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx058

Subject(s) - biology , antibiotic resistance , molecular epidemiology , escherichia coli , multilocus sequence typing , comparative genomics , clade , population , genomics , microbiology and biotechnology , phylogenetics , genetics , genome , gene , genotype , antibiotics , medicine , environmental health

Efforts to treat Escherichia coli infections are increasingly being compromised by the rapid, global spread of antimicrobial resistance (AMR). Whilst AMR in E. coli has been extensively investigated in resource-rich settings, in sub-Saharan Africa molecular patterns of AMR are not well described. In this study, we have begun to explore the population structure and molecular determinants of AMR amongst E. coli isolates from Malawi.

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