Resistance gene transfer: induction of transducing phage by sub-inhibitory concentrations of antimicrobials is not correlated to induction of lytic phage | Zendy

Kinga I. Stanczak-Mrozek | Zendy; Ken Laing | Zendy; Jodi A. Lindsay | Zendy

Open Access

Resistance gene transfer: induction of transducing phage by sub-inhibitory concentrations of antimicrobials is not correlated to induction of lytic phage

Author(s) -

Kinga I. Stanczak-Mrozek,

Ken Laing,

Jodi A. Lindsay

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx056

Subject(s) - lytic cycle , transduction (biophysics) , bacteriophage , microbiology and biotechnology , biology , horizontal gene transfer , antimicrobial , gene , escherichia coli , virology , genetics , genome , virus , biochemistry

Horizontal gene transfer of antimicrobial resistance (AMR) genes between clinical isolates via transduction is poorly understood. MRSA are opportunistic pathogens resistant to all classes of antimicrobial agents but currently no strains are fully drug resistant. AMR gene transfer between Staphylococcus aureus isolates is predominantly due to generalized transduction via endogenous bacteriophage, and recent studies have suggested transfer is elevated during host colonization. The aim was to investigate whether exposure to sub-MIC concentrations of antimicrobials triggers bacteriophage induction and/or increased efficiency of AMR gene transfer.

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