Open AccessThe complexity of minocycline serum protein binding
Author(s) -
Jian Zhou,
Brian T. Tran,
Vincent H. Tam
Publication year - 2017
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkx039
Subject(s) - minocycline , plasma protein binding , medicine , microbiology and biotechnology , biology , antibiotics , pharmacology
Serum protein binding is critical for understanding the pharmacology of antimicrobial agents. Tigecycline and eravacycline were previously reported to have atypical non-linear protein binding; the percentage of free fraction decreased with increasing total concentration. In this study, we extended the investigation to other tetracyclines and examined the factors that might impact protein binding.
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