In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen | Zendy

Hiroshi Nishikawa | Zendy; Yoshiko Fukuda | Zendy; Junichi Mitsuyama | Zendy; Masato Tashiro | Zendy; Akitaka Tanaka | Zendy; Takahiro Takazono | Zendy; Tomomi Saijo | Zendy; Kazuko Yamamoto | Zendy; Shigeki Nakamura | Zendy; Yoshifumi Imamura | Zendy; Taiga Miyazaki | Zendy; Hiroshi Kakeya | Zendy; Yoshihiro Yamamoto | Zendy; Katsunori Yanagihara | Zendy; Hiroshi Mukae | Zendy; Shigeru Kohno | Zendy; Koichi Izumikawa | Zendy

Open Access

In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen

Author(s) -

Hiroshi Nishikawa,

Yoshiko Fukuda,

Junichi Mitsuyama,

Masato Tashiro,

Akitaka Tanaka,

Takahiro Takazono,

Tomomi Saijo,

Kazuko Yamamoto,

Shigeki Nakamura,

Yoshifumi Imamura,

Taiga Miyazaki,

Hiroshi Kakeya,

Yoshihiro Yamamoto,

Katsunori Yanagihara,

Hiroshi Mukae,

Shigeru Kohno,

Koichi Izumikawa

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx020

Subject(s) - cryptococcus gattii , voriconazole , fluconazole , amphotericin b , microbiology and biotechnology , in vivo , cryptococcosis , in vitro , cryptococcus , medicine , antifungal , pharmacology , biology , biochemistry

T-2307, a novel arylamidine, exhibits potent broad-spectrum activities against the majority of fungal pathogens. In this study, the antifungal activity of T-2307 against Cryptococcus gattii was evaluated in comparison with those of amphotericin B, fluconazole and voriconazole in vitro and in vivo .

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