Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity | Zendy

Justin R. Lenhard | Zendy; Visanu Thamlikitkul | Zendy; Fernanda P. Silveira | Zendy; Samira M. Garonzik | Zendy; Xun Tao | Zendy; Alan Forrest | Zendy; Beom Soo Shin | Zendy; Keith S. Kaye | Zendy; Jürgen B. Bulitta | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy; Brian T. Tsuji | Zendy

Open Access

Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity

Author(s) -

Justin R. Lenhard,

Visanu Thamlikitkul,

Fernanda P. Silveira,

Samira M. Garonzik,

Xun Tao,

Alan Forrest,

Beom Soo Shin,

Keith S. Kaye,

Jürgen B. Bulitta,

Roger L. Nation,

Jian Li,

Brian T. Tsuji

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkx002

Subject(s) - colistin , acinetobacter baumannii , sulbactam , polymyxin , polymyxin b , meropenem , microbiology and biotechnology , population , medicine , carbapenem , drug resistance , pharmacology , antibiotics , pseudomonas aeruginosa , antibiotic resistance , biology , bacteria , imipenem , genetics , environmental health

The emergence of polymyxin resistance threatens to leave clinicians with few options for combatting drug-resistant Acinetobacter baumannii . The objectives of the current investigation were to define the in vitro emergence of polymyxin resistance and identify a combination regimen capable of eradicating A. baumannii with no apparent drug susceptibilities.

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