Macrolide resistance inLegionella pneumophila: the role of LpeAB efflux pump | Zendy

Clémence Massip | Zendy; Ghislaine Descours | Zendy; Christophe Ginévra | Zendy; Patricia Doublet | Zendy; Sophie Jarraud | Zendy; Christophe Gilbert | Zendy

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Macrolide resistance inLegionella pneumophila: the role of LpeAB efflux pump

Author(s) -

Clémence Massip,

Ghislaine Descours,

Christophe Ginévra,

Patricia Doublet,

Sophie Jarraud,

Christophe Gilbert

Publication year - 2017

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw594

Subject(s) - efflux , legionella pneumophila , microbiology and biotechnology , legionnaires' disease , legionella , chemistry , biology , bacteria , biochemistry , genetics

A previous study on 12 in vitro -selected azithromycin-resistant Legionella pneumophila lineages showed that ribosomal mutations were major macrolide resistance determinants. In addition to these mechanisms that have been well described in many species, mutations upstream of lpeAB operon, homologous to acrAB in Escherichia coli , were identified in two lineages. In this study, we investigated the role of LpeAB and of these mutations in macrolide resistance of L. pneumophila .

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