Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa | Zendy

Ruth Goodall | Zendy; David Dunn | Zendy; Peter Nkurunziza | Zendy; Lincoln Mugarura | Zendy; Theresa Pattery | Zendy; Paula Munderi | Zendy; Cissy Kityo | Zendy; Charles F. Gilks | Zendy; Pontiano Kaleebu | Zendy; Deenan Pillay | Zendy; Ravindra K. Gupta | Zendy

Open Access

Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa

Author(s) -

Ruth Goodall,

David Dunn,

Peter Nkurunziza,

Lincoln Mugarura,

Theresa Pattery,

Paula Munderi,

Cissy Kityo,

Charles F. Gilks,

Pontiano Kaleebu,

Deenan Pillay,

Ravindra K. Gupta

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw583

Subject(s) - abacavir , zidovudine , nevirapine , lamivudine , regimen , medicine , virology , viral load , pharmacology , human immunodeficiency virus (hiv) , virus , viral disease , antiretroviral therapy , hepatitis b virus

Lack of viral load monitoring of ART is known to be associated with slower switch from a failing regimen and thereby higher prevalence of MDR HIV-1. Many countries have continued to use thymidine analogue drugs despite recommendations to use tenofovir in combination with a cytosine analogue and NNRTI as first-line ART. The effect of accumulated thymidine analogue mutations (TAMs) on phenotypic resistance over time has been poorly characterized in the African setting.

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