Re-emergence of methicillin susceptibility in a resistant lineage ofStaphylococcus aureus | Zendy

Alice Ledda | Zendy; James Price | Zendy; Kevin Cole | Zendy; Martin Llewelyn | Zendy; Angela Kearns | Zendy; Derrick W. Crook | Zendy; John R. Paul | Zendy; Xavier Didelot | Zendy

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Re-emergence of methicillin susceptibility in a resistant lineage ofStaphylococcus aureus

Author(s) -

Alice Ledda,

James Price,

Kevin Cole,

Martin Llewelyn,

Angela Kearns,

Derrick W. Crook,

John R. Paul,

Xavier Didelot

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw570

Subject(s) - staphylococcus aureus , lineage (genetic) , methicillin resistant staphylococcus aureus , microbiology and biotechnology , biology , genetics , bacteria , gene

MRSA is a leading cause of hospital-associated infection. Acquired resistance is encoded by the mecA gene or its homologue mecC , but little is known about the evolutionary dynamics involved in gain and loss of resistance. The objective of this study was to obtain an expanded understanding of Staphylococcus aureus methicillin resistance microevolution in vivo , by focusing on a single lineage.

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